Axial stretch regulates rat tail collecting lymphatic vessel contractions
نویسندگان
چکیده
منابع مشابه
Lymph flow regulates collecting lymphatic vessel maturation in vivo.
Fluid shear forces have established roles in blood vascular development and function, but whether such forces similarly influence the low-flow lymphatic system is unknown. It has been difficult to test the contribution of fluid forces in vivo because mechanical or genetic perturbations that alter flow often have direct effects on vessel growth. Here, we investigated the functional role of flow ...
متن کاملNitric oxide regulates lymphatic contractions
We appreciate the opportunity to respond to Michael J. Davis’s Letter (1) regarding our paper “Mechanobiological Oscillators Control Lymph Flow” (2). Our model was developed to study phasic contractions and the dynamics of NO and calcium rather than the control of basal tone. Many factors—in addition to NO—affect lymphatic baseline diameter, including inflammatory cytokines and hormones, and th...
متن کاملSynchronization and Random Triggering of Lymphatic Vessel Contractions
The lymphatic system is responsible for transporting interstitial fluid back to the bloodstream, but unlike the cardiovascular system, lacks a centralized pump-the heart-to drive flow. Instead, each collecting lymphatic vessel can individually contract and dilate producing unidirectional flow enforced by intraluminal check valves. Due to the large number and spatial distribution of such pumps, ...
متن کاملRho Kinase Enhances Contractions of Rat Mesenteric Collecting Lymphatics
The mechanisms that control phasic and tonic contractions of lymphatic vessels are poorly understood. We hypothesized that rho kinase ROCK, previously shown to increase calcium (Ca2+) sensitivity in vascular smooth muscle, enhances lymphatic contractile activity in a similar fashion. Contractions of isolated rat mesenteric lymphatic vessels were observed at a luminal pressure of 2 cm H2O in a 3...
متن کاملTbx1 regulates Vegfr3 and is required for lymphatic vessel development
Lymphatic dysfunction causes several human diseases, and tumor lymphangiogenesis is implicated in cancer spreading. TBX1 is the major gene for DiGeorge syndrome, which is associated with multiple congenital anomalies. Mutation of Tbx1 in mice recapitulates the human disease phenotype. In this study, we use molecular, cellular, and genetic approaches to show, unexpectedly, that Tbx1 plays a crit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-62799-x